Developer:
Dow AgroSciences LLC

Method of Trait Introduction:
Conventional breeding - cross hybridization and selection involving transgenic donor(s)

GM Trait s :
Glufosinate herbicide tolerance , Glyphosate herbicide tolerance , Lepidopteran insect resistance , Mannose metabolism , 2,4-D herbicide tolerance

Commercial Trait:
(Stacked)  Herbicide Tolerance + Insect Resistance

Summary of Basic Genetic Modification

Gene Introduced	Gene Source	Product	Function
cry1Fa2	synthetic form of cry1F gene derived from Bacillus thuringiensis var. aizawai	modified Cry1F protein	confers resistance to lepidopteran insects by selectively damaging their midgut lining
cp4 epsps (aroA:CP4)	Agrobacterium tumefaciens strain CP4	herbicide tolerant form of 5-enolpyruvulshikimate-3-phosphate synthase (EPSPS) enzyme	decreases binding affinity for glyphosate, thereby conferring increased tolerance to glyphosate herbicide
pat	Streptomyces viridochromogenes	phosphinothricin N-acetyltransferase (PAT) enzyme	eliminates herbicidal activity of glufosinate (phosphinothricin) herbicides by acetylation
cry2Ab2	Bacillus thuringiensis subsp. kumamotoensis	Cry2Ab delta-endotoxin	confers resistance to lepidopteran insects by selectively damaging their midgut lining
aad-1	synthetic form of the aad-1 gene from Sphingobium herbicidovorans	aryloxyalkanoate dioxygenase 1 (AAD-1) protein	detoxifies 2,4-D herbicide by side-chain degradation and degrades the R-enantiomers of aryloxyphenoxypropionate herbicides
vip3Aa20	Bacillus thuringiensis strain AB88	vegetative insecticidal protein (vip3Aa variant)	confers resistance to feeding damage caused by lepidopteran insects by selectively damaging their midgut
pmi  *	Escherichia coli	Phosphomannose Isomerase (PMI) enzyme	metabolizes mannose and allows positive selection for recovery of transformed plants

 * : Selection Marker/Reporter  

Summary of Regulatory Approvals: Country, Year and Type of Approval

Country	Food direct use or processing	Feed direct use or processing	Cultivation domestic or non-domestic use
Brazil
Japan
Mexico
South Korea
Taiwan

 

Regulatory and Biosafety Information

• Biosafety Clearing House-South Korea
• Brazil - Conselho de Informacoes sobre Biotecnologia (CIB)
• CIBIOGEM - Mexico
• Japan Biosafety Clearing House
• Japan Biosafety Clearing House
• Korea Biosafety Clearing House
• Taiwan Food and Drug Administration